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Thesis

Proteomics-aided search for extracellular matrix signatures of colorectal hepatic metastases ex vivo

Abstract:

Hepatic metastases are one of the most dangerous consequences of colorectal cancer, and their occurrence often results in poor prognosis and death. There is a need to improve survival and quality of life for patients with colorectal liver metastases.

In this work, we utilised mass-spectrometry method to identify proteins characteristic of mouse colorectal liver metastasis matrisome and further confirmed the expression of some of them in liver metastasis by immunohistochemistry.

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Institution:
University of Oxford
Research group:
Ruth Muschel Group
Oxford college:
Jesus College
Department:
Medical Sciences Division - Radiation,Oncology and Biology

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Arseniy Yuzhalin
Publication date:
2014
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:1487cfb0-ecc4-4b21-a593-a9b9f4271f77
Local pid:
ora:10075

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