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Transition metal catalyzed alkylation and synthesis of biotin derivatives

Abstract:

Transition Metal Catalyzed Alkylation

We have reported methodology for the use of methanol as an alkylation reagent using catalytic rhodium or iridium species for the formation of branched products from methyl ketones. The synthetic utility of the dialkylated products was enhanced by performing a regioselective Baeyer-Villiger oxidation which allowed access to ester products. A range of different phosphine ligands were screened, and sterically hindered and electron rich phosp...

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Institution:
University of Oxford
Research group:
Prof Tim Donohoe
Oxford college:
Exeter College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:1467ba98-846c-46e6-9620-e4639ed07e43
Local pid:
ora:11308
Language:
English
Keywords:
Subjects:

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