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Thesis

Investigating the roles of zinc finger homeobox 3 in circadian rhythms

Abstract:

This thesis describes a program of investigation carried out by the author at MRC Harwell that shows, for the first time, that the gene Zfhx3 plays a role in modulating the circadian clock. The work has used the short circuit (Sci) mouse model to assess the molecular and genetic role of Zfhx3 in circadian behaviour and visual processing.

The Sci mutant was identified in an ENU mutagenesis dominant screen at MRC Harwell. The causative mutation was found in a highly conserved region ...

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  • (Dissemination version, pdf, 10.8MB)

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
Magdalen College
Role:
Author

Contributors

Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
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Grant:
Funding agency for:
Edwards, JK
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:1444375c-b7de-425a-a2ed-53b715833737
Local pid:
ora:6807

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