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Decoding human fetal liver haematopoiesis

Abstract:

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here, using single-cell transcriptome profiling of approximately 140,000 liver and 74,000 skin, kidney and yolk sac cells, we identify the repertoire of human blood and immune cells during development. We infer differentiation trajectories from HSC/MPPs and evaluate the influence of the tissue microenvi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
ORCID:
0000-0001-8607-5748
Publisher:
Nature Research Publisher's website
Journal:
Nature Journal website
Volume:
574
Pages:
365-371
Publication date:
2019-10-09
Acceptance date:
2019-09-09
DOI:
EISSN:
1476-4687
Pubs id:
pubs:1062857
UUID:
uuid:13e16c1a-688d-4df6-b44a-f616ea69f2c3
Source identifiers:
1062857
Local pid:
pubs:1062857
Language:
English
Keywords:

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