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Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.

Abstract:

BACKGROUND: Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial genotypic assays screen only common resistance-determining mutations. We used whole-genome sequencing to characterise common and rare mutations predicting drug resistance, or consistency with susceptibility, for all first-line and second-line drugs for tuberculosis. METHODS: Between Sept 1, 2010, and Dec 1, 2013, we sequenc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/s1473-3099(15)00062-6

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
Role:
Author
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Medical Research Council More from this funder
NIHR Oxford Biomedical Research Centre More from this funder
NIHR Oxford Health Protection Research Unit on Healthcare Associated Infection and Antimicrobial Resistance More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
The Lancet. Infectious diseases Journal website
Publication date:
2015-06-11
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:13492e4a-6a52-4690-b46c-e6d74c2b40e3
Source identifiers:
528545
Local pid:
pubs:528545

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