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Journal article

Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.

Abstract:

BACKGROUND: Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial genotypic assays screen only common resistance-determining mutations. We used whole-genome sequencing to characterise common and rare mutations predicting drug resistance, or consistency with susceptibility, for all first-line and second-line drugs for tuberculosis. METHODS: Between Sept 1, 2010, and Dec 1, 2013, we sequenc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s1473-3099(15)00062-6

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Medical Research Council More from this funder
NIHR Oxford Health Protection Research Unit on Healthcare Associated Infection and Antimicrobial Resistance More from this funder
NIHR Oxford Biomedical Research Centre More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet. Infectious diseases Journal website
Publication date:
2015-06-01
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
Source identifiers:
528545
Language:
English
Keywords:
Pubs id:
pubs:528545
UUID:
uuid:13492e4a-6a52-4690-b46c-e6d74c2b40e3
Local pid:
pubs:528545
Deposit date:
2015-07-15

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