Journal article
Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.
- Abstract:
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BACKGROUND: Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial genotypic assays screen only common resistance-determining mutations. We used whole-genome sequencing to characterise common and rare mutations predicting drug resistance, or consistency with susceptibility, for all first-line and second-line drugs for tuberculosis. METHODS: Between Sept 1, 2010, and Dec 1, 2013, we sequenc...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 613.4KB, Terms of use)
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- Publisher copy:
- 10.1016/s1473-3099(15)00062-6
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Funding
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Lancet. Infectious diseases More from this journal
- Publication date:
- 2015-06-01
- DOI:
- EISSN:
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1474-4457
- ISSN:
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1473-3099
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:528545
- UUID:
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uuid:13492e4a-6a52-4690-b46c-e6d74c2b40e3
- Local pid:
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pubs:528545
- Source identifiers:
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528545
- Deposit date:
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2015-07-15
Terms of use
- Copyright holder:
- Walker et al
- Copyright date:
- 2015
- Notes:
- Copyright © Walker et al. Open Access article distributed under the terms of CC-BY. Open Access funded by Medical Research Council.
- Licence:
- CC Attribution (CC BY)
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