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Widening the therapeutic window of thoracic radiotherapy: cardiopulmonary toxicity modelling

Abstract:

Introduction: Prognosis for locally advanced non-small cell lung cancer (LANSCLC) remain poor despite attempts with radiation dose escalation to improve overall survival (OS). A major limitation of radiation dose escalation is normal tissue toxicity. Here, I investigate the hypothesis that cardiac and its substructure irradiation impact OS in LA-NSCLC patients with a dose-volume-time effect. As cardiac avoidance can potentially increase lung toxicity (radiation pneumonitis (RP)...

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Sindu Vivekanandan More by this author

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Funding agency for:
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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