- Abstract:
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Introduction: Prognosis for locally advanced non-small cell lung cancer (LANSCLC) remain poor despite attempts with radiation dose escalation to improve overall survival (OS). A major limitation of radiation dose escalation is normal tissue toxicity. Here, I investigate the hypothesis that cardiac and its substructure irradiation impact OS in LA-NSCLC patients with a dose-volume-time effect. As cardiac avoidance can potentially increase lung toxicity (radiation pneumonitis (RP)...
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- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Copyright date:
- 2019
Thesis
Widening the therapeutic window of thoracic radiotherapy: cardiopulmonary toxicity modelling
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