Molecular magnetic resonance imaging of vascular inflammation using microparticles of iron oxide

Thesis

One approach that has demonstrated success in the field of molecular imaging utilizes microparticles of iron oxide (MPIO) conjugated to specific antibodies and/or peptides to provide contrast effects on MRI in relation to the molecular expression of a specified target. The experimental aims of this thesis were 1) to investigate the ability of VCAM-1 and P-selectin targeted MPIO to detect the expression of VCAM-1 and P-selectin on the activated endothelium in-vitro and in-vivo in mouse mode...

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Authors: Akhtar, A; Asim Akhtar

• Publication date: 2010
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: MRI; molecular imaging; contrast agents; iron oxide; microparticles; vascular inflammation
• Subjects: Stroke; Cardiovascular disease; Medical Sciences; Vascular research; Radiology; Advanced materials; Disease prevention