Structural, functional and evolutionary studies on prolyl-hydroxylases

Thesis

This thesis studies the prolyl-hydroxylase family of 2-oxoglutarate dependent oxygenases from structural, functional and evolutionary perspectives.

The role of prolyl-hydroxylation was first identified in collagen, wherein hydroxyproline was found to stabilise the collagen triple helix. In the 1960s, the presence of hydroxyproline in collagen was found to be a result of enzyme catalysed protein modification. An enzyme, now known as collagen prolyl-4-hydroxylase (CP4H), was found to...

Expand abstract

Authors: Scotti, J

• Publication date: 2014
• DOI: 10.5287/ora-n1ar9y9j5
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: oxygenases; X-ray crystallography; protein syntheis; enzyme
• Subjects: Biochemistry; Chemistry