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Computational modelling and molecular dynamics simulations of ligand-gated ion channels

Abstract:

The Cys-loop ligand-gated super family of ion channels and related proteins have been studied using computational methods. Ligand-gated ion channels (LGIC) are pentameric, neurotransmitter-gated, ion selective receptors which play a key role in synaptic transmission. The nicotinic acetylcholine receptor (nAChR) is the archetypal member of the LGIC family. Found at neuronal-neuronal synapses and neuronalmuscular junctions, it is implicated in a variety of diseases and it plays a ke...

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Institution:
University of Oxford
Department:
Life and Environmental Sciences Division

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Role:
Supervisor
Publication date:
2006
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603850184
URN:
uuid:119c7ccb-e7b2-4da1-a137-40c3289c3ad8
Local pid:
td:603850184

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