Thesis
Structural approaches to targeting RNA terminal uridylytransferases
- Abstract:
-
Let-7 microRNA (miRNA) plays a crucial role in the control of cell differentiation and proliferation, which also makes it a suppressor for the occurrence and development of tumors. Pre-let-7 is one of the intermediates in the maturation process of let-7 and two uridylyltransferases - ZCCHC6/TUT7, and ZCCHC11/TUT4 - play essential roles in the downstream processing of let-7 pre-miRNA. In the absence of RNA binding protein Lin28A, they perform 3’ mono-uridylation, leading to pre-let-7 matura...
Expand abstract
Actions
Access Document
- Files:
-
-
(Preview, Dissemination version, pdf, 26.8MB, Terms of use)
-
Authors
+ Clarendon Fund
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100014748
- Programme:
- Clarendon Scholar at the University of Oxford
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2023-06-09
- ARK identifier:
Terms of use
- Copyright holder:
- Yi, L
- Copyright date:
- 2023
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record