Structural approaches to targeting RNA terminal uridylytransferases

Thesis

Let-7 microRNA (miRNA) plays a crucial role in the control of cell differentiation and proliferation, which also makes it a suppressor for the occurrence and development of tumors. Pre-let-7 is one of the intermediates in the maturation process of let-7 and two uridylyltransferases - ZCCHC6/TUT7, and ZCCHC11/TUT4 - play essential roles in the downstream processing of let-7 pre-miRNA. In the absence of RNA binding protein Lin28A, they perform 3’ mono-uridylation, leading to pre-let-7 matura...

Expand abstract

Authors: Yi, G

• DOI: 10.5287/ora-44wd7xpmk
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: structural studies reveal basis of tumor-suppressor let-7 pre-miRNA uridylation by TUT enzymes regulated by oncogenic Lin28A
• Subjects: Structure