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Thesis

Adaptive changes of influenza virus A/H5N1 neuraminidase in vitro and in vivo

Abstract:

H5N1 adaptation process is thought to primarily involve in changes of the 2 main glycoproteins of influenza virus: hemagglutinin HA, responsible for viral entry via binding with host cell receptors, and neuraminidase NA, a receptor destroying enzyme, promoting release of newly formed virions and preventing their self-aggregation. With their opposing roles in viral replication cycle, one rational assumption is that influenza virus needs to maintain a balance between these 2 proteins activit...

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Institution:
University of Oxford
Oxford college:
Kellogg College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Le Nguyen Truc Nhu
Publication date:
2014
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:1037fb1a-c4a1-4bd4-8b5a-7d7add49e879
Local pid:
ora:11353

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