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Vascular phenotype identification and anti-angiogenic treatment recommendation: a pseudo-multiscale mathematical model of angiogenesis

Abstract:

The development of anti-angiogenic drugs for cancer therapy has yielded some promising candidates, but novel approaches for interventions to angiogenesis have led to disappointing results. In addition, there is a shortage of biomarkers that are predictive of response to anti-angiogenic treatments. Consequently, the complex biochemical and physiological basis for tumour angiogenesis remains incompletely understood. We have adopted a mathematical approach to address these issues, formulating a ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jtbi.2016.03.002

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Funding agency for:
Hutchinson, L
Grant:
EP/G037280/1
More from this funder
Funding agency for:
Hutchinson, L
Grant:
EP/G037280/1
More from this funder
Funding agency for:
Hutchinson, L
Grant:
EP/G037280/1
Publisher:
Elsevier Publisher's website
Journal:
Journal of Theoretical Biology Journal website
Volume:
398
Pages:
162–180
Publication date:
2016-01-01
Acceptance date:
2016-03-03
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
Source identifiers:
611895
Language:
English
Keywords:
Pubs id:
pubs:611895
UUID:
uuid:0fa35a82-1121-47e2-a586-ae27b9faf1aa
Local pid:
pubs:611895
Deposit date:
2016-04-07

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