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Thesis

A functional and structural study of HLA-­B*2705 restricted CTL responses associated with delayed HIV-­1 disease progression

Abstract:

The HIV-1 Gag p24 protein contains the HLA class-1 B*2705 restricted epitope KK10, responses to which are associated with delayed progression. Data from in vitro proteasomal digestion studies from our group has shown the production of a number of C-terminally extended and truncated epitopes containing KK10, produced in far higher quantities during proteasomal digestion than this “optimal epitope” and that the amount of antigen made in proteasomal digestion is instrumental in deter...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Research group:
Astrid Iversen and Lars Fugger
Oxford college:
Green Templeton College
Role:
Author

Contributors

Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
More from this funder
Name:
Medical Research Council
Funding agency for:
Pymm, PG
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:0edd1e9a-e356-45b1-8e31-a4f29e199408
Local pid:
ora:8558
Deposit date:
2014-06-10

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