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Thesis

The function of PRC2 in MLL-AF4 acute lymphoid leukaemia

Abstract:

The MLL-AF4 fusion protein is the most prevalent MLL rearrangement in acute lymphoid leukaemia. It is associated with a very poor prognosis with median overall survival of 10 months in children. Epigenetic therapy is a promising new approach for the treatment haematological malignancies. Predicting response to epigenetic therapy has been difficult, in part due to the lack of sufficient knowledge regarding the molecular mechanism by which these inhibitors exert their anti-leukaemic effects...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:0d8edb01-259f-4d74-8eb4-63732e661374
Deposit date:
2019-09-20

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