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Thesis

Identifying genetic determinants of impaired PfEMP1 export in Plasmodium falciparum-infected erythrocytes

Abstract:

The virulence of Plasmodium falciparum is largely attributed to the ability of asexual blood-stage parasites to cytoadhere to the microvascular endothelium of the human host. This pathogenic behavior is mediated by the primary parasite virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1), an understanding of which is crucial to develop interventions to ameliorate the morbidity and mortality of P. falciparum malaria. The work presented in this thesis describes the ap...

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Institution:
University of Oxford
Research group:
Molecular Parasitology Group
Oxford college:
Green Templeton College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - NDM John Radcliffe

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:0cc3f09c-9178-448b-92f8-8f9564398585
Local pid:
ora:10959

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