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Thesis

Studies towards the total synthesis of manzamine A

Abstract:

This thesis describes studies towards the total synthesis of manzamine A (9), a marine alkaloid. Two routes are presented.

The first route applied a novel palladium-catalysed arylative allene spirocyclisation cascade to the synthesis of manzamine A (9). In the first generation, a short route was developed to access the tricyclic ACE core 263a in only nine steps. The second generation applied the palladium-catalysed cascade to a similar system which utilised non-terminal allene pro-...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Subgroup:
Organic Chemistry
Research group:
Dixon Group
Oxford college:
Wadham College
Role:
Author

Contributors

Division:
MPLS
Department:
History Faculty
Subgroup:
Archaeology Research Lab
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:0ca64b5d-bc7c-4624-b9c2-4b5f7b6967e3
Local pid:
ora:7085

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