Thesis
Organisation of, and ligand-independent signalling by the TCR, with a special emphasis on the pre-TCR
- Abstract:
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Understanding how immune signalling is initiated and regulated spatiotemporally is likely to be helped by investigations of receptor stoichiometry. The pre-TCR expressed by thymocytes shares similarities in structure and signalling components with the mature TCR but, in contrast to the TCR, it has no known ligands. This thesis has therefore analysed the stoichiometry of the pre-TCR using mutagenesis- and imaging-based approaches, and explored how ligand-independent signalling might be ...
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Funding
+ Nuffield Department of Medicine Prize Studentship
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Funding agency for:
Huang, E
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:0c01e3d4-2002-487c-a0b6-09ed20cb223b
- Deposit date:
- 2018-05-23
Terms of use
- Copyright holder:
- Huang, E
- Copyright date:
- 2017
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