- Abstract:
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Understanding how immune signalling is initiated and regulated spatiotemporally is likely to be helped by investigations of receptor stoichiometry. The pre-TCR expressed by thymocytes shares similarities in structure and signalling components with the mature TCR but, in contrast to the TCR, it has no known ligands. This thesis has therefore analysed the stoichiometry of the pre-TCR using mutagenesis- and imaging-based approaches, and explored how ligand-independent signalling might be ...
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- Funding agency for:
- Elizabeth Chi-Fang Huang
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Copyright date:
- 2017
Thesis
Organisation of, and ligand-independent signalling by the TCR, with a special emphasis on the pre-TCR
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Funding
+ Nuffield Department of Medicine Prize Studentship
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