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Thesis

The roles of the homeobox genes ALX4 and MSX2 in skull development

Abstract:

Heritable ossification defects of the skull vault often present as enlarged parietal foramina (PFM), bilateral oval openings of the posterior parietal bones. Isolated PFM may originate from wider defects in infancy and usually show an autosomal dominant mode of transmission, offering unexplored genetic insights into the molecular pathways of calvarial development. Haploinsufficiency of the homeobox gene MSX2, located at 5q34-q35, underlies a fraction of PFM families but the locus can be ex...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Oxford college:
Green Templeton College
Role:
Author

Contributors

Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Publication date:
2004
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:0bb04cdd-540d-41b4-ade9-239d55f94c12
Local pid:
ora:5298
Deposit date:
2011-05-05

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