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Thesis

The roles of CD38 and NAADP in cardiac tissue

Abstract:

Nicotinic acid adenine dinucleotide phosphate (NAADP) is an endogenous molecule that releases calcium ions (Ca2+) from acidic endolysosomal stores. This Ca2+-mobilising molecule is known to play a role in modulating cardiac excitation-contraction coupling and pathophysiology.

The first part of the thesis focuses on understanding the mechanistic details of NAADP actions, particularly during the flight and fight response of the heart. Paced ventricular myocytes, which ...

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Division:
MSD
Role:
Author

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Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:0b9f9ac6-28e1-4e8e-ba77-4b5361816a2e
Deposit date:
2019-03-17

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