Intracellular chloride and hydrogen ion dynamics in the nervous system

Thesis

Synaptic transmission in the nervous system involves the activation of receptor proteins that permit rapid transmembrane fluxes of ions. Ionic gradients across the membrane determine the direction and driving force for the flow of ions and are therefore crucial in setting the properties of synaptic transmission. These ionic gradients are established by a variety of mechanisms, including pump and transporter proteins. However, the gradients can be affected by periods of neural activity, whi...

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Authors: Raimondo, J

• Publication date: 2012
• DOI: 10.5287/ora-a4rqyxg1g
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: neurons; neuroscience; pH; astrocytes; epilepsy; chloride
• Subjects: Medical Sciences; Biology (medical sciences); Biosensors; Physiology and anatomy