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Journal article

Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance

Abstract:

In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) α-synuclein (αS) pathology is seen that displays a predictable topographic distribution. There are two staging/categorization systems, i.e. Braak’s and McKeith’s, currently in use for the assessment of αS pathology. The aim of these diagnostic strategies in pathology is, in addition to assess the stage/severity of pathology, to assess the probabilities of the related clinical symptomatology i.e. dementia and extrapyramidal sympto...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00401-008-0346-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
European Union
Grant:
LSHM-CT-2006-037050
Publisher:
Springer
Journal:
Acta Neuropathologica More from this journal
Volume:
115
Issue:
4
Pages:
399-407
Publication date:
2008-02-23
Acceptance date:
2008-01-30
DOI:
EISSN:
1432-0533
ISSN:
0001-6322
Keywords:
Pubs id:
pubs:579211
UUID:
uuid:0aff4dcf-1888-479b-ac80-0bc7dac36a45
Local pid:
pubs:579211
Source identifiers:
579211
Deposit date:
2015-12-09

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