Thesis
Regulation and role of TBX2 and TBX3 in tumour progression
- Abstract:
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TBX2 and TBX3 belong to the T-box family of transcription factors and are im- portant in embryonic development and tumourigenesis. Overexpression of TBX2/3 has been observed in several types of cancer, promoting tumour proliferation, senescence bypass and invasiveness.
Given their important contribution to tumour progression, it might be of therapeutic benefit to pharmacologically inhibit their expression for cancer treatment. To identify novel regulators of TBX2/3, we carried out ...
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
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- Copyright holder:
- Lu, S
- Copyright date:
- 2020
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