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Thesis

Small molecule colorimetric and fluorescent probes for specific protein detection

Abstract:

This thesis describes the design, synthesis, analysis, mechanistic evaluation and optimisation of small molecule probes for the specific detection of proteins, focusing on the target protein human arylamine N-acetyltransferase type 1 (HUMAN(NAT1)) and its murine homologue, mouse arylamine N-acetyltransferase type 2 (MOUSE(NAT2)). The HUMAN(NAT1) gene is reported to be one of the most highly overexpressed genes in estrogen-receptor-positive (ER+) breast tumours, ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Prof. Angela Russell
Oxford college:
Hertford College
Role:
Author

Contributors

Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor
Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor

More from this funder
Funding agency for:
Egleton, JE
Grant:
C38302/A12450

Publication date:
2015
DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
Keywords:
Subjects:
UUID:
uuid:0a1a1c80-8055-491a-920a-3e17f7919e93
Local pid:
ora:12526
Deposit date:
2016-07-08
ARK identifier:

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