- Abstract:
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Human immunodeficiency virus (HIV) Rev and Hepatitis B virus (HBV) e-antigen are both viral proteins that have key functions in their respective viral replication cycles. Both have evaded crystallization for decades due to their tendency to aggregate and/or form higher-order species. In this thesis the structure determination of HIV Rev and HBV e-antigen is presented—achieved via complexing with monoclonal antibody Fab fragments—and their structures are analysed.
HIV Rev is a small ...
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- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- URN:
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uuid:09c109e6-ddc0-435a-9cdd-1c01808ead92
- Local pid:
- ora:10811
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Michael A. DiMattia
- Copyright date:
- 2012
Thesis
Structural and biophysical studies of HIV Rev and HBV e-antigen
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