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Thesis

Structural and biophysical studies of HIV Rev and HBV e-antigen

Abstract:

Human immunodeficiency virus (HIV) Rev and Hepatitis B virus (HBV) e-antigen are both viral proteins that have key functions in their respective viral replication cycles. Both have evaded crystallization for decades due to their tendency to aggregate and/or form higher-order species. In this thesis the structure determination of HIV Rev and HBV e-antigen is presented—achieved via complexing with monoclonal antibody Fab fragments—and their structures are analysed.

HIV Rev is a small ...

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Institution:
University of Oxford
Research group:
Stuart / Grimes
Oxford college:
Magdalen College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Division of Structural Biology

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:09c109e6-ddc0-435a-9cdd-1c01808ead92
Local pid:
ora:10811

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