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Thesis

Actuation of DNA cages and their potential biological applications

Abstract:

DNA cages are polyhedra self-assembled from synthetic oligonucleotides in a one-pot process. The main system described in this thesis is a reconfigurable, wire-framed DNA tetrahedron in nanometre-scale. On one of its vertices this tetrahedron has an overhang that can hybridise with a specific sequence of nucleic acids and open the cage.

We describe the design of a reconfigurable cage that remained closed under physiological conditions and only opened in the presence of an appropriat...

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Institution:
University of Oxford
Oxford college:
St Anne's College
Department:
Mathematical,Physical & Life Sciences Division - Physics - Condensed Matter Physics

Contributors

Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:0983ed77-77f6-4d15-9187-52aff44299ec
Local pid:
ora:12174
Language:
English
Keywords:
Subjects:

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