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Investigating the ligandability of plant homeodomains

Abstract:

Plant homeodomains (PHDs) are protein domains which bind to the N-terminal region of histone 3 (H3) in a manner dependent on the post-transitional modification state of residues near the N-terminus of H3. For example some PHDs will only bind H3 if lysine 4 (K4) is trimethylated, whereas other PHDs will only bind H3 if K4 is unmodified. PHDs play a crucial role in gene regulation in cells and mutations and translocations of PHDs have been linked to disease states.

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Division:
MSD
Department:
NDM
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:091d9d1f-a76f-462b-84a2-85e808a9bc48
Deposit date:
2016-03-21

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