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Investigation of the role of ASPP2 in tumourigenesis

Abstract:

The skin is the site where two of the most common types of epithelial cancer, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), arise. In this work, we have investigated how ASPP2, a member of a family of proteins that interact with the p53 family, can affect skin tumourigenesis. ASPP2 is expressed in the squamous epithelia of various organs, localising exclusively in the upper and most differentiated layers. We show here that Balb/c ASPP2-null and heterozygous mice develop spo...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:08fd41ee-14f4-4715-9629-b20955be4eb8
Local pid:
ora:9691

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