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Thesis

The role of the TSC-complex in selective neuronal vulnerability in Alzheimer’s disease

Abstract:

The overall aim of this thesis was to investigate the role of the Tuberous Sclerosis (TSC) complex in selective neuronal vulnerability (SNV) of the CA1 region in Alzheimer’s disease (AD). This aim was addressed through a combination of neuropathological and in vitro studies.

We first investigated whether a Hamartin (TSC1) loss of function predisposes rat hippocampal neurons to Aβ1-42-induced cell death and tau phosphorylation. We employed a rat hippocampal model exposed ...

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Division:
MSD
Department:
Clinical Neurosciences
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:08ba12f3-a66b-43da-b5c5-b939fb8444bc
Deposit date:
2019-09-23

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