Thesis

The role of the TSC-complex in selective neuronal vulnerability in Alzheimer’s disease

Abstract:: The overall aim of this thesis was to investigate the role of the Tuberous Sclerosis (TSC) complex in selective neuronal vulnerability (SNV) of the CA1 region in Alzheimer’s disease (AD). This aim was addressed through a combination of neuropathological and in vitro studies.

We first investigated whether a Hamartin (TSC1) loss of function predisposes rat hippocampal neurons to Aβ_1-42-induced cell death and tau phosphorylation. We employed a rat hippocampal model exposed ...
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APA Style

Adriaanse, B. (2019). The role of the TSC-complex in selective neuronal vulnerability in Alzheimer’s disease [PhD thesis]. University of Oxford.

MLA Style

Adriaanse, B. The Role of the TSC-Complex in Selective Neuronal Vulnerability in Alzheimer’s Disease. University of Oxford, 2019.

Chicago Style

Adriaanse, B. 2019. “The Role of the TSC-Complex in Selective Neuronal Vulnerability in Alzheimer’s Disease.” PhD thesis, University of Oxford.
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Authors

+ Adriaanse, B More by this author

Division:: MSD
Department:: Clinical Neurosciences
Role:: Author

Contributors

Role:: Supervisor

Role:: Supervisor

+ NDCN Prize Studentship More from this funder

DOI:: 10.5287/ora-rvpbmrz9e
Type of award:: DPhil
Level of award:: Doctoral
Awarding institution:: University of Oxford

UUID:: uuid:08ba12f3-a66b-43da-b5c5-b939fb8444bc
Deposit date:: 2019-09-23

Terms of use

Copyright holder:: Adriaanse, B; Bryan Adriaanse.
Copyright date:: 2019

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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