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Journal article

MRE11A isoform expression associated with outcome following radiotherapy in muscle-invasive bladder cancer does not alter cell survival and DNA double-strand break repair following ionising radiation

Abstract:

Background: DNA double strand breaks are the cytotoxic lesions produced by ionising radiation. Critical for the repair of these lesions is the DNA damage response protein MRE11 which, in a complex with RAD50 and NBS1, mediates DNA damage signalling and double-strand break repair. We previously found the presence of an MRE11 germline single nucleotide polymorphism (SNP), rs1805363 (G > A), to be associated with poor outcome following radiotherapy (RT) and increased expre...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3233/BLC-190209

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
Publisher:
IOS Press
Journal:
Bladder Cancer More from this journal
Volume:
5
Issue:
2
Pages:
147-157
Publication date:
2019-08-16
Acceptance date:
2019-06-24
DOI:
EISSN:
2352-3735
ISSN:
2352-3727
Keywords:
Pubs id:
pubs:1020886
UUID:
uuid:081f8255-9518-43f7-bccd-c1d589b81715
Local pid:
pubs:1020886
Source identifiers:
1020886
Deposit date:
2019-06-24

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