Molecular mechanisms of premature ageing in a worm model of human Werner syndrome

Thesis

Investigating the biological basis of ageing is both fascinating and medically relevant, as we strive to understand both how organisms age, and how our knowledge might be put to good use in an increasingly long-lived human population. Despite the complexity of ageing biology, it is very striking that longevity, in a wide variety of organisms, can be modified by manipulating single genes. In this thesis, I investigate phenotypes associated with mutations in C. elegans homologues of...

Expand abstract

Authors: Lees, H; Hayley Lees

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: Ageing; Werner syndrome; genetics; genomic instability; RecQ helicase; C. elegans; longevity
• Subjects: Biochemistry; Genetics (life sciences)