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Thesis

The influence of invariant natural killer T cells on myeloid-derived suppressor cell generation and function

Abstract:

The absence of invariant Natural Killer T cells (iNKT cells) in mice infected with Influenza A virus (flu) has previously been shown to augment the expansion of Myeloid-derived suppressor cells (MDSCs), a bone marrow derived population that powerfully suppress the development of viral and tumor immune responses. Moreover, iNKT cell adoptive transfer into flu-infected mice has been shown to abolish the expansion and flu-induced suppressive activity of the MDSCs in a CD1d- and CD40-dependent...

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Institution:
University of Oxford
Research group:
MRC Human Immunology Unit
Oxford college:
Lincoln College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author

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Role:
Supervisor
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Funding agency for:
Ramon Arscott
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:07ab563a-7455-4f69-bca0-3b409b72d2f7
Local pid:
ora:9280
Language:
English
Keywords:
Subjects:

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