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Thesis

Role of the nuclear envelope in regulation of ageing

Abstract:

Cellular senescence is a phenomenon characterised by stable and durable states of proliferative arrest induced by various stress stimuli. The abundance of senescent cells in tissues increases over a lifetime and, among other functions, they have been proposed to play a pivotal role in ageing. Hutchinson-Gilford progeria syndrome (HGPS) is a disease characterised by segmental premature ageing. It is caused by the expression of a persistently farnesylated lamin A isoform. Strikingly, HGPS pa...

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Division:
MSD
Department:
Pathology Dunn School
Department:
University of Oxford
Role:
Author

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Department:
University of Oxford
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:0766d5da-e570-43ef-9a0c-5f39a3a15e30
Deposit date:
2016-07-06

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