Thesis
Probing presynaptic regulation of dopamine release in health and disease
- Abstract:
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Dopamine (DA) plays a key role in regulating behaviours controlled within the basal ganglia, including movement, action selection, and motivation. Consequently, dysfunction of dopaminergic neurotransmission can result in psychomotor disorders, including Parkinson’s disease and addiction disorders. Striatal DA release is not only regulated by somatodendritic activity in the midbrain, but also local circuits acting on the extensive axonal arbour of DA neurons that can modulate and drive DA r...
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- Files:
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(Preview, Dissemination version, pdf, 13.1MB, Terms of use)
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Authors
Contributors
+ Cragg, S
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
- ORCID:
- 0000-0001-9677-2256
+ Brimblecombe, K
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
- ORCID:
- 0000-0003-0809-7292
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
-
2025-10-19
- ARK identifier:
Terms of use
- Copyright holder:
- Rishi Anand
- Copyright date:
- 2023
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