Thesis
Role of the actin cytoskeleton in regulating LYVE-1 lateral diffusion and function
- Abstract:
-
The lymphatic endothelial receptor LYVE-1 investigated here is a weak binder to its ligand hyaluronan (HA) and uses receptor clustering to achieve the avidity required for stable interaction to HA. These clustering based interactions are highly dynamic and are often controlled by several molecular players that contribute to receptor functional changes. One such contributor is the cortical actin cytoskeleton. As the actin cytoskeleton lies immediately below the membrane surface, it creates c...
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Authors
Contributors
+ Fritzsche, M
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Contributor
+ Banerji, S
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Contributor
+ Jackson, D
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Supervisor
+ Eggeling, C
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Supervisor
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
-
uuid:073fb882-83fd-4cfd-8d99-608f2ba4959f
- Deposit date:
- 2017-12-18
Related Items
Terms of use
- Copyright holder:
- Stanly, T
- Copyright date:
- 2017
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