Molecular dissection of ionotropic glutamate receptor delta-family interactions with trans-synaptic proteins

Thesis

Correct functioning of the brain relies upon the precise connectivity between the billions of neurons that make up this crucial organ. Aberrations in the formation of these elaborate neural networks lead to neurodegenerative and neuropsychiatric disorders. A synapse-spanning molecular triad, involving members of the Neurexin, Cbln and ionotropic glutamate receptor delta families of proteins, is crucial for the accurate formation and proper function of synapses in the cerebellum. This trans...

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Authors: Clay, J; Jordan Clay

• Publication date: 2013
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: membrane proteins; trans-synaptic protein complexes; X-ray crystallography
• Subjects: Molecular biophysics (biochemistry); Crystallography; Membrane proteins; Polymers Amino acid and peptide chemistry; Biochemistry; Protein chemistry