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Thesis

A glycopore for bacterial sensing

Abstract:

Increasing antibiotic resistance has created a need to develop rapid and reliable methods to identify bacteria and provide pertinent information to ensure suitable antibiotics or sugar therapeutics can be chosen for treatment. Carbohydrate structures attached to proteins on host cell surfaces provide a binding point for many pathogens, including bacteria. These structures can be mimicked using single monosaccharides glycosylated to alpha-hemolysin (alpha-HL). Alpha-HL is a beta-barrel pore-fo...

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Institution:
University of Oxford
Research group:
Hagan Bayley Laboratory
Oxford college:
Oriel College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Samantha Jane Shanley
Publication date:
2009
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:06fe9bce-6bf2-4f61-b4d8-014cb9df3fc0
Local pid:
ora:3384

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