Thesis icon

Thesis

How does the chromatin remodeler ATRX identify its targets in the genome?

Abstract:

ATRX is a chromatin remodeling protein associated with X-linked Alpha-Thalassemia Mental Retardation syndrome and cancers that use the Alternative Lengthening of Telomere pathway. In the absence of ATRX there is a DNA damage response associated with telomeres and the expression of certain genes are perturbed. Recent findings (Law et al, 2010 Cell) have shown that ATRX is preferentially enriched at GC-rich tandem repeats in the genome. The mechanism for this localisation is unknown but may ...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Oxford college:
St Anne's College
Department:
Medical Sciences Division - Clinical Laboratory Sciences

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:04e402d5-f19e-45d9-b245-d553b7dcae7d
Local pid:
ora:11900

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP