Thesis
How does the chromatin remodeler ATRX identify its targets in the genome?
- Abstract:
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ATRX is a chromatin remodeling protein associated with X-linked Alpha-Thalassemia Mental Retardation syndrome and cancers that use the Alternative Lengthening of Telomere pathway. In the absence of ATRX there is a DNA damage response associated with telomeres and the expression of certain genes are perturbed. Recent findings (Law et al, 2010 Cell) have shown that ATRX is preferentially enriched at GC-rich tandem repeats in the genome. The mechanism for this localisation is unknown but may ...
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Funding
+ Medical Research Council; European Commission
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Funding agency for:
Diu Thi Thanh Nguyen
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
-
uuid:04e402d5-f19e-45d9-b245-d553b7dcae7d
- Local pid:
- ora:11900
Item Description
- Language:
- English
- Keywords:
- Subjects:
Terms of use
- Copyright holder:
- Diu Thi Thanh Nguyen
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA
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