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Thesis

Neuronal control of cardiac excitability in pro-hypertensive states

Abstract:

Hypertension is associated with marked cardiac sympathetic over-activity and end organ hyper-responsiveness. The sympathetic dysfunction is caused by aberrant calcium (Ca2+) handling resulting in enhanced neurotransmission. However, it remains unclear whether the sympathetic neuron or the myocytes is the primary driver behind the initiation and maintenance of the autonomic phenotype. The work in this thesis characterises the Ca2+ dysfunction and regulation at the memb...

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Department:
University of Oxford
Role:
Copyright Holder, Author

Contributors

Department:
University of Oxford
Role:
Supervisor
Department:
University of Bristol
Role:
Examiner
Department:
University of Oxford
Role:
Examiner
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Grant:
OXION
Funding agency for:
Project
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Grant:
travel grant
Funding agency for:
Hege Ekeberg Larsen
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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