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Thesis

Population genetics of rifampicin-resistant pseudomonas aeruginosa

Abstract:

Antibiotic resistance is generally associated with a cost in terms of reduced competitive fitness in the absence of antibiotics. Despite this `cost of resistance', the cessation of antibiotic treatment does not result in significant reductions in the prevalence of resistance. The maintenance of resistance, in spite of the costs, has been attributed to the rarity of reversion mutations, relative to compensatory mutations at other loci in the genome. However, the large size of bacteria popu...

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Institution:
University of Oxford
Research group:
MacLean
Oxford college:
Somerville College
Department:
Mathematical,Physical & Life Sciences Division - Zoology

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:044b9258-4f10-4e77-9ff6-aa4035cec33b
Local pid:
ora:8873
Language:
English
Keywords:
Subjects:

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