Thesis icon

Thesis

The identification and validation of Auger electron-emitting radiopharmaceuticals targeting telomerase for cancer therapy

Abstract:

Telomerase is expressed in the majority (>85%) of tumours but not in differentiated normal tissue. This enzyme catalyses the elongation of telomeres – a process critical for continued cell proliferation. Telomerase is a potential novel target for molecularly-targeted radiotherapy (mRT), due to its nuclear localization and expression profile. The radiolabelling of telomerase inhibitors may accelerate and enhance the cytotoxicity of such molecules, as a result of irradiation of the DNA.

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Oxford college:
Brasenose College
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:040d10f6-c69b-41d3-b73f-7c47c4053db2
Local pid:
ora:8399

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP