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Thesis

Biochemical characterisation of KDM2A

Abstract:

Mammalian genomes are characterised by unique regions of non-methylated DNA known as CpG islands (CGIs). These genomic elements are characterised by a high density of CpGs and an elevated GC content compared to the surrounding, bulk of the genome. CGIs are prevalently associated with the 5’ end of genes and represent key nucleation sites where specific transcription factors and chromatin modifiers are recruited to impact on gene function.

This thesis is focused at understanding the...

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  • (Dissemination version, pdf, 23.4MB)

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Corpus Christi College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:030faa1d-5d3c-4066-9e9f-a44cd13cf85c
Local pid:
ora:7060
Deposit date:
2013-07-19

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