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Thesis

Biochemical characterisation of KDM2A

Abstract:

Mammalian genomes are characterised by unique regions of non-methylated DNA known as CpG islands (CGIs). These genomic elements are characterised by a high density of CpGs and an elevated GC content compared to the surrounding, bulk of the genome. CGIs are prevalently associated with the 5’ end of genes and represent key nucleation sites where specific transcription factors and chromatin modifiers are recruited to impact on gene function.

This thesis is focused at understanding the...

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Institution:
University of Oxford
Oxford college:
Corpus Christi College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
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Funding agency for:
Jin Chuan Zhou
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:030faa1d-5d3c-4066-9e9f-a44cd13cf85c
Local pid:
ora:7060

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