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Thesis

Developing small molecule inhibitors of bromodomain-histone interactions

Abstract:

Bromodomains, protein modules found in 46 human chromatin-associated proteins, bind to acetylated lysine residues (KAc), and modulate the formation of complex protein scaffolds, which are often involved in transcription. The work in this dissertation focuses on the development of small molecule inhibitors for the BRD9 bromodomain, which is a component of nucleosome remodelling complexes, and has been linked to lung and cervical cancers.

The lead molecule was based on the triazole K...

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Role:
Supervisor, Author
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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