Thesis
Investigating protective mechanisms of anti-sporozoite vaccines
- Abstract:
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Malaria remains a leading cause of childhood mortality, thereby highlighting the need for an effective vaccine. R21 is a virus-like particle-based (VLP-based) vaccine displaying the immunodominant NANP repeat region of the circumsporozoite protein (CSP) of Plasmodium falciparum. R21 is biosimilar to the current leading malaria vaccine candidate, RTS,S, in that CSP epitopes are found on the VLP surface. However RTS,S has a higher ratio of unbound Hepatitis B surface antigen (HBsAg)...
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- Files:
-
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(Preview, Dissemination version, pdf, 14.9MB, Terms of use)
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Authors
Contributors
+ Ewer, K
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
- ORCID:
- 0000-0001-9827-9836
+ Hill, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Pubs id:
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1624873
- Local pid:
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pubs:1624873
- Deposit date:
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2024-02-19
- ARK identifier:
Terms of use
- Copyright holder:
- Bellamy, DG
- Copyright date:
- 2023
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