Kinetic investigations of the oxygen entry pathway of the hypoxia-inducible factor (HIF) prolyl hydroxylase 2

Thesis

Human hypoxia inducible factor (HIF) is responsible for mediating the body’s response to low O₂ availability. The levels and activity of HIF are regulated by four Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases, prolyl-hydroxylase domains 1-3 (PHD 1-3) and factor-inhibiting HIF (FIH), collectively termed the HIF hydroxylases. The PHDs catalyse hydroxylation of specific prolyl residues in the N - and C - terminal oxygen-dependent degradation domains of HIF-α, targeting it for de...

Expand abstract

Authors: Kearney, L

• DOI: 10.5287/ora-zgqbvqadb
• Type of award: MSc by Research
• Level of award: Masters
• Awarding institution: University of Oxford