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Thesis

Methodology for the conversion of tetramates to pyroglutamates, and a study of their biological activity

Abstract:

Highly functionalised pyroglutamates, molecules of interest for their biological uses and applications, are readily accessible from a bicyclic tetramic acid as a substrate for functionalisation at C3 and C4 of tetramic acid ring. These molecules have structural features common to pyroglutamate and pyrrolinone-containing natural products and this thesis particularly focuses on the development of novel routes to 3-substituted and 3,4-disubstituted pyroglutamic acid derivatives.

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Department:
Department of Chemistry, University of Oxford

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Role:
Supervisor
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Grant:
BDCS-2015-52
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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