Development of antimalarial human monoclonal antibodies against Plasmodium falciparum

Thesis

Advances in high-throughput isolation of neutralizing human monoclonal antibodies (mAbs) have enabled development of mAb-based therapeutics for many viruses (e.g., HIV-1, Ebola, SARS-CoV-2). This approach has recently been applied to isolate antimalarial human mAbs against the Plasmodium falciparum circumsporozoite protein (CSP) on sporozoites (SPZ) and reticulocyte-binding protein homolog 5 (RH5) on merozoites (MZ). CSP and RH5 are leading malaria vaccine targets because they are respecti...

Expand abstract

Authors: Wang, LT

• DOI: 10.5287/ora-n6e5v2vkq
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: malaria; Plasmodium falciparum; monoclonal antibodies; circumsporozoite protein
• Subjects: Immunology, infectious diseases, vaccinology