Guidelines for the investigation and management of Transient Leukaemia of Down Syndrome

Journal article

Methodology This guideline was compiled according to the British Society for Haematology (BSH) process at (http://www.bcshguidelines.com). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) nomenclature was used to evaluate levels of evidence and to assess the strength of recommendations. The GRADE criteria can be found at http://www.gradeworkinggroup.org.

Literature review details Ovid MEDLINE and Ovid EMBASE were searched systematically for publications in English from 1980 to the end of 2015 using the key words Transient Abnormal Myelopoiesis, Transient Myeloproliferative Disorder, Transient Leukaemia, and Down Syndrome. Specific searches relating to fetal disease and hepatic parameters were also performed. References from relevant publications were also searched.

Working group membership The guideline group was selected to be representative of UK‐based medical experts with invited representatives from the British Association of Perinatal Medicine and the Royal College of Paediatrics and Child Health.

Review Review of the manuscript was performed by the BSH Guidelines General Haematology Task Force, the BSH Guidelines Committee and the General Haematology sounding board of BSH. It was also placed on the members section of the BSH website for comment. Further comments were invited from a sounding board of the Childhood Leukaemia Clinicians'27 Network, the Childhood Cancer and Leukaemia Group (CCLG), the Royal College of Paediatrics and Child Health, the British Association of Perinatal Medicine (BAPM) and patient representatives identified through the Down Syndrome Association; these organisations do not necessarily approve or endorse the contents.

The objective of this guideline is to provide healthcare professionals with guidance on the investigation and management of patients with Transient Leukaemia of Down Syndrome (TL‐DS). Individual patient circumstances may dictate an alternative approach. This is the first BSH guideline on this topic and is in date at time of publication. Any updates will be posted on the BSH Guidelines website (http://www.bcshguidelines.com).

Authors: Tunstall, O; Bhatnagar, N; James, B; Norton, A; O'Marcaigh, AS

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Wiley
• Journal: British Journal of Haematology
• Volume: 182
• Issue: 2
• Pages: 200-211
• Publication date: 2018-06-19
• Acceptance date: 2018-03-05
• DOI: 10.1111/bjh.15390
• EISSN: 1365-2141
• ISSN: 0007-1048
• Pmid: 29916557
• Keywords: transient myeloproliferative disorder; Transient Leukaemia; transient abnormal myelopoiesis; neonatal leukaemia; Down syndrome