Biology and management of transient abnormal myelopoiesis (TAM) in children with Down syndrome.

Journal article

Children with Down syndrome (DS) have an increased risk of Acute Myeloid Leukaemia (ML-DS), particularly megakaryoblastic leukaemia, which is clonally -related to the neonatal myeloproliferative syndrome, Transient Abnormal Myelopoiesis (TAM) unique to infants with DS. Molecular, biological, and clinical data indicate that TAM is initiated before birth when fetal liver haematopoietic cells trisomic for chromosome 21 acquire mutations in GATA1. TAM usually resolves spontaneously by 6 months; h...

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Authors: Roy, A; Roberts, I; Vyas, P

• Publication status: Published
• Journal: Seminars in fetal and neonatal medicine
• Volume: 17
• Issue: 4
• Pages: 196-201
• Publication date: 2012-08-01
• DOI: 10.1016/j.siny.2012.02.010
• EISSN: 1878-0946
• ISSN: 1744-165X
• Language: English
• Keywords: Humans; Neoplasm Regression, Spontaneous; Leukemia, Myeloid, Acute; Blood Cell Count; Myelopoiesis; GATA1 Transcription Factor; Child Development; Blood Cells; Down Syndrome; Infant, Newborn; Leukemia, Megakaryoblastic, Acute; Child; Infant