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Journal article

Biology and management of transient abnormal myelopoiesis (TAM) in children with Down syndrome.

Abstract:

Children with Down syndrome (DS) have an increased risk of Acute Myeloid Leukaemia (ML-DS), particularly megakaryoblastic leukaemia, which is clonally -related to the neonatal myeloproliferative syndrome, Transient Abnormal Myelopoiesis (TAM) unique to infants with DS. Molecular, biological, and clinical data indicate that TAM is initiated before birth when fetal liver haematopoietic cells trisomic for chromosome 21 acquire mutations in GATA1. TAM usually resolves spontaneously by 6 months; h...

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Publication status:
Published

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Publisher copy:
10.1016/j.siny.2012.02.010

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics, Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research
Role:
Author
Journal:
Seminars in fetal and neonatal medicine
Volume:
17
Issue:
4
Pages:
196-201
Publication date:
2012-08-05
DOI:
EISSN:
1878-0946
ISSN:
1744-165X
URN:
uuid:fff6866d-8591-486f-bd56-14d3fd51e8e7
Source identifiers:
321083
Local pid:
pubs:321083

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