Journal article
Heavy chain deposition disease presenting with raised anti-GBM antibody levels; a case report
- Abstract:
- Background Monoclonal immunoglobulin deposition disease (MIDD) is a rare condition accounting for < 1% of histopathological diagnoses made on kidney biopsy1. The best outcomes are seen in those diagnosed and treated promptly, but delay to diagnosis is common with the largest series reporting a median time from onset of renal impairment to diagnosis of 12 months2. Here, we report a case of the heavy chain subset of MIDD presenting with positive anti-glomerular basement membrane (anti-GBM) antibodies obscuring the true diagnosis. Case presentation Here, we present a challenging case presenting with oedema, haematoproteiuria, and new renal impairment. Anti-GBM antibodies were positive and prompted treatment as atypical anti-GBM disease. However, they were ultimately proven to be monoclonal and secondary to myeloma. The final diagnosis facilitated effective myeloma treatment which led to complete remission and independence from renal replacement therapy. Conclusions This case reinforces the importance of comprehensive histopathological and haematological assessment in making the correct diagnosis. Here it facilitated effective treatment and recovery of renal function.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.3MB, Terms of use)
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- Publisher copy:
- 10.1186/s12882-020-01837-2
Authors
- Publisher:
- BioMed Central
- Journal:
- BMC Nephrology More from this journal
- Volume:
- 21
- Article number:
- 175
- Place of publication:
- England
- Publication date:
- 2020-05-12
- Acceptance date:
- 2020-04-30
- DOI:
- EISSN:
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1471-2369
- Pmid:
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32398029
- Language:
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English
- Keywords:
-
- Pubs id:
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1106887
- Local pid:
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pubs:1106887
- Deposit date:
-
2021-11-18
Terms of use
- Copyright holder:
- Turner et al.
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- Licence:
- CC Attribution (CC BY)
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