Outcome of half-dose photodynamic therapy in chronic central serous chorioretinopathy with fovea-involving atrophy

van Rijssen, TJ; van Dijk, EHC; Scholz, P; MacLaren, RE; Fauser, S; Downes, SM; Hoyng, CB; Boon, CJF

Journal article

Outcome of half-dose photodynamic therapy in chronic central serous chorioretinopathy with fovea-involving atrophy

Abstract:: Abstract Purpose To evaluate the clinical outcomes after half-dose photodynamic therapy (PDT) in chronic central serous chorioretinopathy (cCSC) patients with pre-existent fovea-involving atrophy. Methods In this retrospective study, cCSC patients who had a window defect of the retinal pigment epithelium (RPE) on fluorescein angiography (FA), compatible with RPE atrophy, prior to half-dose PDT were included. Results Thirty-four cCSC eyes with typical findings of cCSC on multimodal imaging, and fovea-involving RPE atrophy on FA, were included. At the first visit after PDT (at a median of 1.8 months after half-dose PDT), 20 eyes (59%) had a complete resolution of SRF (p < 0.001), while this was the case in 19 eyes (56%) at final visit (median of 11.3 months after half-dose PDT; p < 0.001). The mean BCVA in Early Treatment of Diabetic Retinopathy Study letters was 71. 2 ± 15.9 at last visit before PDT, which increased to 74.1 ± 14.1 at first visit after PDT (p = 0.093, compared with baseline), and changed to 73.0 ± 19.1 at final visit (p = 0.392, compared with baseline). Both at first visit after PDT and at final visit, a significant decrease in subfoveal choroidal thickness was observed (p = 0.032 and p = 0.004, respectively). Conclusions Half-dose PDT in cCSC patients with pre-existing fovea-involving atrophy may lead to anatomical changes, but not to functional improvements. Ideally, cCSC should be treated with half-dose PDT before the occurrence of such atrophy.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

van Rijssen, T. J., van Dijk, E. H. C., Scholz, P., MacLaren, R. E., Fauser, S., Downes, S. M., Hoyng, C. B., & Boon, C. J. F. (2020). Outcome of half-dose photodynamic therapy in chronic central serous chorioretinopathy with fovea-involving atrophy. Graefe's Archive for Clinical and Experimental Ophthalmology, 259(4), 905–910.

MLA Style

van Rijssen, TJ, et al. “Outcome of Half-Dose Photodynamic Therapy in Chronic Central Serous Chorioretinopathy with Fovea-Involving Atrophy.” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 259, no. 4, 2020, pp. 905–10.

Chicago Style

Rijssen, TJ van, EHC van Dijk, P Scholz, et al. 2020. “Outcome of Half-Dose Photodynamic Therapy in Chronic Central Serous Chorioretinopathy with Fovea-Involving Atrophy.” Graefe's Archive for Clinical and Experimental Ophthalmology 259 (4): 905–10.
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